Hydrochloric Acid → HCID 178496783, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 14.1 g (0.071 mole) of 2-hydroxy-3-(1H-imidazol-4-ylmethyl)-benzonitrile (prepared in example 1.1 above) in 400 ml of methanol is cooled to -45° C. and saturated with gaseous hydrochloric acid. The suspension is allowed to return to 10° C. and gaseous hydrochloric acid is bubbled through the suspension for 4 hours more at that temperature. The suspension is cooled to 5° C. and kept at that temperature for 20 hours. The precipitate which has formed is filtered off and 11.4 g of methyl 2-hydroxy-3-(1H-imidazol-4-ylmethyl)-benzenecarboximidate are obtained in the form of a white solid which is used as such in the following step.

Provenance & Evidence