Hydroxyamine hydrochloride → HCID 178513292, compound

Participants

Reaction Steps

3 g (0.015 mole) of 2-hydroxy-3-(1H-imidazol-4-ylmethyl-)benzonitrile (prepared in example 1.1 above) are dissolved in 100 ml of methanol and 1.15 g (0.0165 mole) of hydroxylamine hydrochloride and 1.84 g of sodium acetate are added thereto. The resulting mixture is then heated at the reflux temperature for 20 hours. The methanol is evaporated under reduced pressure and the residue is taken up in 100 ml of water. The resulting aqueous solution is neutralized to pH 7 by addition of an aqueous sodium bicarbonate solution. The white precipitate thus formed is filtered off, dried under vacuum and recrystallized from methanol. 1.6 g of N,2-dihydroxy-3-(1H-imidazol-4-ylmethyl)-benzenecarboximidamide, identical to the product obtained in example 2.5 above, are obtained. Yield 46%.

Provenance & Evidence