Bromine → HCID 20095710, compound

HRID 1770235Notes

Reaction equation

HRID 1770235 reaction equation
[CH2:1]([O:3][C:4]1[C:9]([O:10][CH3:11])=[C:8]([O:12][CH2:13][CH3:14])[CH:7]=[C:6]([CH3:15])[C:5]=1[OH:16])[CH3:2].[Br:17]Br>C(Cl)(Cl)Cl>[Br:17][C:7]1[C:8]([O:12][CH2:13][CH3:14])=[C:9]([O:10][CH3:11])[C:4]([O:3][CH2:1][CH3:2])=[C:5]([OH:16])[C:6]=1[CH3:15]

Participants

4

Reactant 2

HCID 24408BromineHCID 20095715HCID 20095715, compound

Product 1

HCID 20095710HCID 20095710, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

40 g of 2,4-diethoxy-3-methoxy-6-methylphenol prepared in Referential Example 6 was dissolved in 200 ml of chloroform, and 10 ml of bromine was added thereto and cooled by ice while stirring. Ice water was added to the reaction mixture, and the mixture was subjected to liquid-liquid separation. The organic phase was washed with saturated saline and dried over anhydrous magnesium sulfate, and the solvent was distilled off to prepare 54 g of the product compound as a light yellow oleaginous substance.

Workup

  1. temperaturecooled by ice
  2. customthe mixture was subjected to liquid-liquid separation
  3. washThe organic phase was washed with saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled off
  6. customto prepare 54 g of the product compound as a light yellow oleaginous substance

Sources & evidence

ORD record
ord-61e6e0fb5a5c4d9cbb3d0c5865550f66
Source dataset
uspto-grants-1995_01
Patent number
US05385942

Reaction notes

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