Pyridine → HCID 67771069, compound

HRID 1770263Notes

Reaction equation

HRID 1770263 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([OH:25])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[CH:26]=[C:27]([NH2:30])[CH:28]=[CH:29][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].C[N:32]1[C:38](=O)[O:37]C(=O)[C:34]2=[CH:40][CH:41]=[CH:42][CH:43]=[C:33]12.N1C=CC=C[CH:45]=1>>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[C:18]([C:23]([OH:25])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:15][CH:16]=2)[C:8]2[CH:26]=[C:27]([N:30]([C:38]([NH:32][C:33]3[CH:34]=[CH:40][CH:41]=[CH:42][CH:43]=3)=[O:37])[CH3:45])[CH:28]=[CH:29][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 1049PyridineHCID 25160N-Methylisatoic anhydrideHCID 10363552HCID 10363552, compound

Product 1

HCID 67771069HCID 67771069, compound

Procedure

A solution of 0.8 g (2.00 mMol) of 4'-[[2-n-butyl-6-aminobenzimidazol-1-yl]-methyl]biphenyl-2-carboxylic acid and 0.9 g of N-methyl-isatoic acid anhydride in 3 ml of pyridine is refluxed for 48 hours, then evaporated to dryness, the residue is suspended in about 5 ml of methylene chloride, suction filtered, washed with a further 5 ml of methylene chloride and dried.

Workup

  1. customevaporated to dryness
  2. filtrationsuction filtered
  3. washwashed with a further 5 ml of methylene chloride
  4. customdried

Sources & evidence

ORD record
ord-5fc4e3a183ef4d81abf3c6bbc9e9ef93
Source dataset
uspto-grants-1995_01
Patent number
US05385925

Reaction notes

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