HCID 15715412, compound → HCID 15715413, compound

Participants

Reaction Steps

Compound (12) (500 mg, 1.32 mmol) was hydrogenated over Pd(OH)2 (20%, 95 mg, ca. 0.1 eq.) in EtOH (15 mL) at atmospheric pressure for 12 hrs. Filtration through Celite™ and concentration left 387 mg (100%) of white solids. m.p. 100°-102° C. IR (CHCl3) 3100-3400, 3020, 2930, 1715, 1615, 1590, 1450, 1390, 1295, 1170, 1050 cm-1 ; 1H NMR (CDCl3, 250 MHz) δ6.42 (d, 1H, J=2.4 HZ, ArH), 6.27 (d, 1H, J=2.4 Hz, ArH), 5.50 (br s, 1H, OH), 3.04 (br t 2H, J=7.7 Hz), 1.69 (s, 6H, CH3), 1.20-1.65 (m, 1OH), 0.88 (t, 3H, J=7.2 Hz, CH3).

Provenance & Evidence