Methyl iodide → HCID 57944912, compound

HRID 1770546Notes

Reaction equation

HRID 1770546 reaction equation
[CH2:1]([CH:8]1[NH:12][C:11](=[O:13])[N:10]([C:14]2[CH:15]=[N:16][N:17]([CH2:19][C:20]3[C:21]([CH3:26])=[N:22][O:23][C:24]=3[CH3:25])[CH:18]=2)[C:9]1=[O:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[CH3:29]>>[CH2:1]([CH:8]1[N:12]([CH3:29])[C:11](=[O:13])[N:10]([C:14]2[CH:15]=[N:16][N:17]([CH2:19][C:20]3[C:21]([CH3:26])=[N:22][O:23][C:24]=3[CH3:25])[CH:18]=2)[C:9]1=[O:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 57422463HCID 57422463, compound

Product 1

HCID 57944912HCID 57944912, compoundYield 95%

Procedure

Prepared as in example 10-5 from 5-benzyl-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-2) and iodomethane. Yield: 95%. 1H NMR (CDCl3, 400 MHz): δ 2.04 (s, 3H), 2.15 (s, 3H), 2.96 (s, 3H), 3.24-3.23 (m, 2H, J=4.0 Hz), 4.23-4.21 (m, 1H), 5.00 (s, 2H), 7.24-7.23 (m, 5H, J=4.0 Hz), 7.70 (s, 1H), 7.87 (s, 1H).

Sources & evidence

ORD record
ord-ad43447a32754af8a023af1fffc59f49
Source dataset
uspto-grants-2016_02
Patent number
US09247759B2

Reaction notes

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