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HRID1770579

反应详情

EQUATION

反应方程式

HRID 1770579 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(CCBr)cc1OC
HCID11470602

3,4-Dimethoxyphenethyl bromide

C10H13BrO2

结构：Cc1noc(C)c1Cn1cc(N2C(=O)CNC2=O)cn1
HCID57422424

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CCN2CC(=O)N(c3cnn(Cc4c(C)noc4C)c3)C2=O)cc1OC
HCID57944978

未命名化合物

收率 36%

PROCEDURE

实验过程

Prepared as in example 10-52 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example10-1) and 3,4-dimethoxyphenethyl bromide. Yield: 36%. MS M+H calculated 440.19. Found 440.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.26 μM.