HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromopropyl)benzene → 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-phenylpropyl)imidazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromopropyl)benzene | HCID 12503 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione | HCID 57422424 | — |
| Product | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-phenylpropyl)imidazolidine-2,4-dione | HCID 57422497 | 36% |
Reaction Steps
Prepared as in example 10-52 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)imidazolidine-2,4-dione (example 10-1) and (3-bromopropyl)benzene. Yield: 36%. MS M+H calculated 394.2. Found 394.2. The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.26 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09247759B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5bd06c155d0f4cc5a733d1fbec6bbb34 |
| Source note | uspto-grants-2016_02 |