Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1770593Generated: October 26, 2026

3-((tert-Butyldimethylsilyl)oxy)-4-methoxybenzaldehyde → Ethyl 2-(3-(tert-butyldimethylsilyloxy)-4-methoxybenzylamino)-2-methylpropanoate

https://huagongshe.com/reaction/1770593

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-((tert-Butyldimethylsilyl)oxy)-4-methoxybenzaldehydeHCID 359558—
ReactantEthyl 2-amino-2-methylpropanoate hydrochlorideHCID 22343822—
ProductEthyl 2-(3-(tert-butyldimethylsilyloxy)-4-methoxybenzylamino)-2-methylpropanoateHCID 5952440294%

Reaction Steps

Prepared as in Example 12-1b from 3-(tert-butyldimethylsilyloxy)-4-methoxybenzaldehyde (Example 12-2c) and ethyl 2-amino-2-methylpropanoate hydrochloride. Yield 94%, colorless liquid. MS 382 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09247759B2
Source datasetuspto-grants-2016_02
ORD IDord-f7e6aafdc39a43639788cbc7c874e8c9
Source noteuspto-grants-2016_02