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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1770601Generated: October 30, 2026

Ethyl L-valinate hydrochloride → (S)-ethyl 2-(3-(tert-butyldimethylsilyloxy)benzylamino)-3-methylbutanoate

https://huagongshe.com/reaction/1770601

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl L-valinate hydrochlorideHCID 87181—
Reactant3-(t-Butyldimethylsilyloxy)benzaldehydeHCID 11207111—
Product(S)-ethyl 2-(3-(tert-butyldimethylsilyloxy)benzylamino)-3-methylbutanoateHCID 5952441597%

Reaction Steps

Prepared as in Example 12-1b from 3-(tert-butyldimethylsilyloxy)benzaldehyde (Example 12-1c) and (S)-ethyl 2-amino-3-methylbutanoate hydrochloride. Yield 97%, colorless liquid. MS 352 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09247759B2
Source datasetuspto-grants-2016_02
ORD IDord-0ddfbf646fdf4b66b2de0a6d5f0baaf8
Source noteuspto-grants-2016_02