Veratraldehyde → Methyl 1-(3,4-dimethoxybenzylamino)cyclopropanecarboxylate

HRID 1770606Notes

Reaction equation

HRID 1770606 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH:6]=O.Cl.[NH2:14][C:15]1([C:18]([O:20][CH3:21])=[O:19])[CH2:17][CH2:16]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[CH2:6][NH:14][C:15]1([C:18]([O:20][CH3:21])=[O:19])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8419VeratraldehydeHCID 12760695Methyl 1-aminocyclopropane-1-carboxylate hydrochloride

Product 1

HCID 59524359Methyl 1-(3,4-dimethoxybenzylamino)cyclopropanecarboxylateYield 82%

Procedure

Prepared as in Example 12-1b from 3,4-dimethoxybenzaldehyde and methyl 1-aminocyclopropanecarboxylate hydrochloride. Yield 82%. MS 266 (MH+).

Sources & evidence

ORD record
ord-156c5c8f76d543e9a436b04db21feaf0
Source dataset
uspto-grants-2016_02
Patent number
US09247759B2

Reaction notes

Loading…