3-(Methoxymethyl)benzaldehyde → Methyl 1-(3-(methoxymethyl)benzylamino)cyclopropanecarboxylate

HRID 1770607Notes

Reaction equation

HRID 1770607 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=O.Cl.[NH2:13][C:14]1([C:17]([O:19][CH3:20])=[O:18])[CH2:16][CH2:15]1>>[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH:13][C:14]1([C:17]([O:19][CH3:20])=[O:18])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 122456233-(Methoxymethyl)benzaldehydeHCID 12760695Methyl 1-aminocyclopropane-1-carboxylate hydrochloride

Product 1

HCID 59524365Methyl 1-(3-(methoxymethyl)benzylamino)cyclopropanecarboxylateYield 82%

Procedure

Prepared as in Example 12-1b from 3-(methoxymethyl)benzaldehyde (Example 12-14b) and methyl 1-aminocyclopropanecarboxylate hydrochloride. Yield 82%. MS 250 (MH+).

Sources & evidence

ORD record
ord-d03b7c563d0e471b98c8a81366535d7a
Source dataset
uspto-grants-2016_02
Patent number
US09247759B2

Reaction notes

Loading…