HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Xylyl bromide → HCID 53375154, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Xylyl bromide | HCID 6992 | — |
| Reactant | 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione | HCID 59524388 | — |
| Product | HCID 53375154 | HCID 53375154 | — |
Reaction Steps
Prepared as in Example 12-16 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione (Example 12-16a) and 1-(bromomethyl)-2-methylbenzene. MS 408 (MH+). The title compound was shown to inhibit hT2R08 bitter receptor and had an IC50 of 0.1 μM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09247759B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-c51c6d578cd34f6f9d3d71f76f9e06b0 |
| Source note | uspto-grants-2016_02 |