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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1770633Generated: October 31, 2026

tert-Butyldimethylsilyl chloride → Methyl 6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

https://huagongshe.com/reaction/1770633

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyldimethylsilyl chlorideHCID 28928—
ReactantMethyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochlorideHCID 66974808—
ProductMethyl 6-(tert-butyldimethylsilyloxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylateHCID 5952438783%

Reaction Steps

Prepared as in Example 12-1c from methyl 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride (Example 13-3c) and tert-butylchlorodimethylsilane. Yield 83%, yellowish. MS 322 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09247759B2
Source datasetuspto-grants-2016_02
ORD IDord-1973b1312a8148c1b2be688a580f5b01
Source noteuspto-grants-2016_02