Ether hydrochloride → 1092977-06-4

HRID 1770653Notes

Reaction equation

HRID 1770653 reaction equation
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH:12](C(OC(C)(C)C)=O)[CH2:13][NH:14][CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4].[ClH:28].CCOCC>>[ClH:28].[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([CH2:12][CH2:13][NH:14][CH2:15][C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 10953452Ether hydrochlorideHCID 68487077HCID 68487077, compound

Product 1

HCID 684834361092977-06-4Yield 95%

Procedure

A solution of 2-[2-(3-butoxyphenyl)-(tert-butoxycarbonyl)ethylamino]-N,N-dimethylacetamide (9.6 g, 25.3 mmol) in HCl/Et2O (127 ml) was stirred at room temperature for 16 h. The solvent was evaporated under reduced pressure, the residue was ground with a mixture of Et2O/iPr2O 50/50, filtered and washed with Et2O/iPr2O to obtain the title compound as white solid (1.71 g, yield 95%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionthe residue was ground with a mixture of Et2O/iPr2O 50/50
  3. filtrationfiltered
  4. washwashed with Et2O/iPr2O

Sources & evidence

ORD record
ord-422eb71e87c2455d88d1ffe5fda2c62a
Source dataset
uspto-grants-2016_02
Patent number
US09248116B2

Reaction notes

Loading…