HCID 67509059, compound → HCID 86665515, compound

HRID 1770690Notes

Reaction equation

HRID 1770690 reaction equation
[OH:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][S:10]([CH2:13][CH2:14][C:15]([NH:18]C(=O)OCC1C=CC=CC=1)([CH3:17])[CH3:16])(=[O:12])=[O:11]>CO.[Pd]>[NH2:18][C:15]([CH3:17])([CH3:16])[CH2:14][CH2:13][S:10]([CH2:9][CH2:8][O:7][CH2:6][CH2:5][O:4][CH2:3][CH2:2][OH:1])(=[O:12])=[O:11]

Participants

4

Reactant 1

HCID 67509059HCID 67509059, compound

Product 1

HCID 86665515HCID 86665515, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of benzyl 4-(2-(2-(2-hydroxyethoxy)ethoxy)ethylsulfonyl)-2-methylbutan-2-ylcarbamate (223 mg, 0.534 mmol) in methanol (5 ml) was added palladium on carbon (10%, 35 mg). The suspension was put under a N2 atmosphere and H2 (1.3 atmospheres) introduced. The suspension was stirred for 1 hour, filtered (0.45 um, PTFE), and concentrated in vacuo. The residue was used without any further purification. LRMS (ESI/APCI) m/z 284 [M+H]+.

Workup

  1. additionH2 (1.3 atmospheres) introduced
  2. filtrationfiltered (0.45 um, PTFE)
  3. concentrationconcentrated in vacuo
  4. customThe residue was used without any further purification

Sources & evidence

ORD record
ord-9d8b7071383b47c78cd7385dd2088b87
Source dataset
uspto-grants-2016_02
Patent number
US09248117B2

Reaction notes

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