Sodium borohydride → HCID 67515018, compound

Participants

Reaction Steps

Ethyl 5-(benzyloxycarbonylamino)-5-methyl-3-oxohexanoate (3.49, 10.9 mmol) was dissolved in ethanol (100 ml). Sodium borohydride (1.64 g, 43.4 mmol) was added to the mixture, and the reaction mixture was stirred for 3 hours at room temperature. The reaction was quenched with 1 N HCl, and the mixture was stirred for 1 hour. The mixture was extracted with ethylacetate, and the combined organic layers were dried over sodium sulfate, filtered, and purified by column chromatography (0 to 4% methanol on dichloromethane) to give 2.14 g (70%) of the title compound.

Provenance & Evidence