Ammonia → 4-(Hydroxymethyl)-1,4-dimethylimidazolidin-2-one

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Reaction Steps

In a round bottom flask, a mixture of 2-amino-2-methyl-3-(methylamino)propan-1-ol hydrochloride (3.3 g, 21 mmol) and urea (1.26 g, 21 mmol) were heated in a 200° C. sand bath for 1 hour until ammonia gas ceased to evolve. The resultant mixture was suspended in dichloromethane and filtered to remove insoluble material. The organic solution was concentrated to a black solid and purified by purified by column chromatography (1 to 12% methanol in dichloromethane) to give the desired product as a tan oil (1.3 g, 9.0 mmol, 45% yield). 1H NMR (400 MHz, CDCl3) δ 1.26 (s, 3H), 2.76 (s, 3H), 3.07-3.9 (d, J=8.8 Hz, 1H), 3.36-3.36 (d, J=8.8 Hz, 1H), 3.43-3.44 (d, J=2.1 Hz, 2H), 3.46 (s, 1H). 13C NMR (100 MHz, CDCl3/MeOD) δ 23.5, 30.1, 50.0, 55.7, 67.7, 161.9. LRMS (ESI/APCI) m/z 145 [M+H]+.

Provenance & Evidence