Hydroxyethyl imidazolidinone → HCID 56966448, compound

Participants

Reaction Steps

A solution of 1-(2-hydroxyethyl)imidazolidin-2-one (418 mg, 3.2 mmol) in MeOH (6 ml) was cooled to 0° C. tert-Butylhypochlorite (450 ul, 4 mmol) was added. The resulting solution was stirred for 90 min and then concentrated under reduced pressure. The crude material was purified by column chromatography (0 to 12% methanol in dichloromethane) to give a white solid (317 mg, 1.93 mmol, 60%). 1H NMR (400 MHz, D2O) δ 3.28-3.31 (t, J=5.3 Hz, 2H), 3.47-3.51 (m, 2H), 3.56-3.59 (m, 2H), 3.62-3.64 (t, J=5.3 Hz, 2H). 13C NMR (100 MHz, D2O) δ 43.31, 46.6, 51.9, 58.3, 163.9. LRMS (ESI/APCI) m/z 165 [M+H]+.

Provenance & Evidence