Sodium Methoxide → HCID 57562885, compound

HRID 1770837Notes

Reaction equation

HRID 1770837 reaction equation
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[C:9]([CH3:12])[C:10]=1F)(=[O:4])=[O:3].[CH3:16][O-:17].[Na+]>>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[C:9]([CH3:12])[C:10]=1[O:17][CH3:16])(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 57562895HCID 57562895, compound

Product 1

HCID 57562885HCID 57562885, compound

Procedure

The resulting 3-aminosulfonyl-4-fluoro-5-methylnitrobenzene (0.940 g, 4 mmol) was stirred with 25% methanolic NaOMe (1.00 mL) at 60° C. for overnight. The resulting solution was then filtered through a pad of Celite, washed with methanol and the methanolic solution was concentrated to give 3-aminosulfonyl-4-methoxy-5-methylnitrobenzene. LCMS: purity: 100%, MS (m/e): 247 (MH+).

Workup

  1. filtrationThe resulting solution was then filtered through a pad of Celite
  2. washwashed with methanol
  3. concentrationthe methanolic solution was concentrated

Sources & evidence

ORD record
ord-e6028c0ee2334fc8820b27a5bdfab4d4
Source dataset
uspto-grants-2016_02
Patent number
US09248190B2

Reaction notes

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