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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1770854Generated: November 4, 2026

2-Methyl-2-(4-nitrophenoxy)propanamide → 2-(4-Aminophenoxy)-2-methylpropanamide

https://huagongshe.com/reaction/1770854

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-2-(4-nitrophenoxy)propanamideHCID 12321522—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product2-(4-Aminophenoxy)-2-methylpropanamideHCID 57562907—

Reaction Steps

2-(4-Nitrophenoxy)-2-methylpropanamide was dissolved in methanol (50 mL) and to the solution was added 10% Pd—C (500 mg). The reaction mixture was reacted under hydrogen atmosphere (˜40 psi) for 1 h. The catalyst was filtered off over celite. The filtrate was evaporated to give 2-(4-aminophenoxy)-2-methylpropanamide as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09248190B2
Source datasetuspto-grants-2016_02
ORD IDord-8df75659d1b2463eb7f368e9cf9cff3f
Source noteuspto-grants-2016_02