HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Tapentadol Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (betaR,gammaR)-gamma-ethyl-N,N,beta-trimethyl-3-(phenylmethoxy)benzenepropanamine | HCID 60164845 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tapentadol Hydrochloride | HCID 9838021 | 90% |
Reaction Steps
20 mL of water and 20 mL of concentrated hydrochloric acid were added to the product of Example 38 (2.5 g, 8 mmol), then it was reacted at 80° C. for 17 hours, after that, the reaction solution was concentrated and recrystallized with isopropanol and isopropyl ether to give the target 1.9 g, yield: 90%. The HNMR spectrum data is the same as that in Example 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249084B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-ae3605cf9a9b400aaff0c19b92126691 |
| Source note | uspto-grants-2016_02 |