HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → Benzyl 2-bromo-2,2-difluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 2-Bromo-2,2-difluoroacetic acid | HCID 2773282 | — |
| Solvent | Cyclohexane | HCID 8078 | — |
| Product | Benzyl 2-bromo-2,2-difluoroacetate | HCID 10378165 | — |
Reaction Steps
This compound was prepared according to Example 2a from bromodifluoroacetic acid (9.82 g; 68.7 mmol), benzyl alcohol (7.0 g; 65 mmol), and p-toluenesulphonic acid monohydrate (50 mg) in cyclohexane (120 mL). The crude product obtained after evaporation was used as is without any further workup in 3b.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249086B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-73f25d56bc8441348449fcc0b66adb7e |
| Source note | uspto-grants-2016_02 |