HCID 90034562, compound → HCID 90034513, compound

HRID 1771033Notes

Reaction equation

HRID 1771033 reaction equation
[C:1]([NH:8][CH2:9][C:10](=[O:29])[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]CC1C=CC=CC=1)=[O:20])=[O:14])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[H][H]>[Pd].C(O)C>[C:1]([NH:8][CH2:9][C:10](=[O:29])[CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[O:14])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

5

Reactant 2

HCID 90034562HCID 90034562, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 90034513HCID 90034513, compoundYield 102.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

This compound was prepared from the product of 5a (5.40 g; 13.2 mmol), 10% palladium on activated carbon (250 mg), hydrogen gas, and 96% ethanol (100 mL) as described in Example 2c. 4.30 g product was obtained (yellowish oil) which was used in 5c without any further workup.

Sources & evidence

ORD record
ord-9030fb2f50034339991e2b1b89645a56
Source dataset
uspto-grants-2016_02
Patent number
US09249086B2

Reaction notes

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