HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Tert-butyl 4-(bromomethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | 4-(Bromomethyl)benzoic acid | HCID 22599 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tert-butyl 4-(bromomethyl)benzoate | HCID 11414578 | 39.5% |
Reaction Steps
This compound was prepared from 4-(bromomethyl)benzoic acid (2.15 g; 10.0 mmol), t-butyl alcohol (4.8 mL; 50 mmol), anhydrous MgSO4 (4.8 g; 40 mmol), and concentrated sulphuric acid in dichloromethane (40 mL) as described in Example 6a. After 14 days, the mixture was worked up as described in Example 6a. 1.07 g (39%) product was obtained (white solid). The product was used in 7b without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249086B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5990551fc5764802b5b68e390248c119 |
| Source note | uspto-grants-2016_02 |