Benzyl 6-bromohexanoate → HCID 90034528, Verbindung

HRID 1771044Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1771044
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].[C:17]([NH:27][CH2:28][C:29](=[O:35])[CH2:30][CH2:31][C:32]([O-:34])=[O:33])([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18].[Cs+]>>[C:17]([NH:27][CH2:28][C:29](=[O:35])[CH2:30][CH2:31][C:32]([O:34][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])=[O:33])([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18]

Komponenten

3

Edukt 2

HCID 562258Benzyl 6-bromohexanoateHCID 90034572caesium 5-(Cbz-amino)-4-oxopentanoate

Produkt 1

HCID 90034528HCID 90034528, Verbindung

Versuchsvorschrift

This compound was prepared from the product of 9a (0.77 g; 2.7 mmol) and 8b (1.0 g; 2.5 mmol) according to Procedure C. The reaction time was 2 days. The crude product was purified on a 75×45 mm silica gel 60 column eluted with ethyl acetate-hexane (1:1) (1000 mL) collecting 14×50 mL fractions. Fractions containing the product (5-7) were collected, and after evaporation 0.52 g (44%) product was obtained (amber oil that solidified to a waxy solid on standing in the freezer).

Aufarbeitung

  1. customThe crude product was purified on a 75×45 mm silica gel 60 column
  2. washeluted with ethyl acetate-hexane (1:1) (1000 mL)
  3. customcollecting 14×50 mL fractions
  4. additionFractions containing the product (5-7)
  5. customwere collected
  6. customafter evaporation 0.52 g (44%) product
  7. customwas obtained (amber oil that

Quellen und Nachweise

ORD-Eintrag
ord-8c6984cb8f1540f698753554248e2566
Quelldatensatz
uspto-grants-2016_02
Patentnummer
US09249086B2

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