HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monobasic potassium phosphate → 11-carboxyundecyl 5-(Boc-amino)-4-oxopentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monobasic potassium phosphate | HCID 516951 | — |
| Reactant | 2,2,2-trichloroethyl 12-[5-(Boc-amino)-4-oxopentanoyloxy]dodecanoate | HCID 118207107 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 11-carboxyundecyl 5-(Boc-amino)-4-oxopentanoate | HCID 90034503 | 93.1% |
Reaction Steps
This compound was prepared from the product of 14b (1.38 g; 2.5 mmol) in tetrahydrofuran (25 mL) following the procedure in Example 12c and using the same quantities of 1 M KH2PO4 solution and zinc powder. Following work-up, 1.0 g (93%) product was obtained (pale yellow oil).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249086B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-fddf8714651c4ee88ec6496d3c1dae1f |
| Source note | uspto-grants-2016_02 |