HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phthalimidopropionic acid → Tert-butyl 2-(2-(2-(3-(1,3-dioxoisoindolin-2-yl)propanamido)ethoxy)-ethoxy)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phthalimidopropionic acid | HCID 76859 | — |
| Reactant | tert-butyl N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate | HCID 9881394 | — |
| Reactant | (Z)-N-(3-(3,4-dichlorophenyl)propyl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide | HCID 21947512 | — |
| Product | Tert-butyl 2-(2-(2-(3-(1,3-dioxoisoindolin-2-yl)propanamido)ethoxy)-ethoxy)ethylcarbamate | HCID 86728174 | 97.3% |
Reaction Steps
By appropriate application of the method used to synthesize Intermediate 5, tert-butyl 2-(2-(2-aminoethoxy)ethoxy)ethylcarbamate (400 mg, 1.6 mmol) and 3-(1,3-dioxoisoindolin-2-yl)propanoic acid (388 mg, 1.8 mmol) were combined to provide Intermediate 7A (700 mg, 87% yield). HPLC/MS (Method C) RT=2.80 min, [M+H]+ 450.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249096B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-ee995a9af48f462186e6f69e0380c8e6 |
| Source note | uspto-grants-2016_02 |