反应详情

54 g o-phenylenediamine (0.5 mol), 300 mL glacial acetic acid and 98 g 3-ethoxy-3-imino propionic acid ethyl ester (0.5 mol) were stirred at refluxing for 2 hours. After concentration under reduced pressure, the residual solution was poured into ice water and a solid was isolated. After sucking filtration, washing with water and a little amount of ethanol, and drying, 83 g off-white solid was obtained. Yield: 82%, MS: 205 (M+1).

1. temperatureat refluxing for 2 hours
2. concentrationAfter concentration under reduced pressure
3. additionthe residual solution was poured into ice water
4. customa solid was isolated
5. filtrationfiltration
6. washwashing with water
7. dry with materiala little amount of ethanol, and drying