Sodium Hydroxide → HCID 71268633, compound

Participants

Reaction Steps

To a solution of N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)-N-(propylsulfonyl)propane-1-sulfonamide (30 mg, 0.06 mmol, 1 eq.) in MeOH (5 mL) was added NaOH solution (1 N, 0.12 mL, 0.12 mmol, 2 eq.). The resulting mixture was stirred at rt for 1 h, then concentrated. The residue was purified via flash column (PE/EA=1/1, v/v) to afford N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide (20 mg, 84.7%). LRMS (M−H+) m/z calculated 390.1. found 389.8. 1H NMR (CDCl3, 400 MHz) δ 8.93-8.98 (dd, 2H), 8.45 (s, 1H), 8.38-8.41 (m, 1H), 8.25-8.28 (m, 1H), 7.79-7.82 (m, 1H), 7.07-7.11 (t, 1H), 6.71 (s, 1H), 3.10-3.14 (m, 2H), 1.87-1.92 (m, 2H), 1.04-1.08 (t, 3H).

Provenance & Evidence