反应详情

2-amino 2-cyano acetamide (1.4 g, 0.01473 mol, 1 eq) in pyridine (15 ml) is stirred for 1 h at room temperature, to this 2,6-dimethyl isonicotinyl chloride (2.5 g, 0.1473 mol, 1 eq) [prepared by stirring a mixture of 2,6-dimethyl isonicotinic acid (2.5 g, 0.0465 mol, 1 eq) in thionyl chloride (15 ml) at 85° C. for 2 hr, thionyl chloride was removed in vacuum under nitrogen] is added at 0° C. and the reaction mixture is stirred at room temperature for 14 h, after the completion of the reaction pyridine is removed under vacuum and the crude product is purified by column chromatography to afford (1.5 g) of the titled compound;

1. customprepared
2. customthionyl chloride was removed in vacuum under nitrogen]
3. additionis added at 0° C.
4. stirringthe reaction mixture is stirred at room temperature for 14 h
5. customafter the completion of the reaction pyridine
6. customis removed under vacuum
7. customthe crude product is purified by column chromatography