tert-Butyl piperazine-1-carboxylate → HCID 89838245, compound

Participants

Reaction Conditions

Reaction Steps

The synthesis is carried out in argon condition. 2 g (10.7 mmol) of N-Boc-piperazine and 2.06 g (10.7 mmol) of 3-tert-butyl-4-methoxybenzaldehyde are mixed in 30 ml of dry dichloromethane. After dissolution 2 drops of acetic acid is added, then 4.24 g (20 mmol) of NaBH(OAc)3 is added and the mixture is stirred for 12 h at 20° C. Then 20 ml of 5% NaHCO3 aqueous solution is added dropwise with care to the reaction mixture. The organic layer is separated, washed with 5% Na2CO3 solution, dried over sodium sulfate, filtered off and concentrated in vacuum at 50÷80° C. The residue (3.5 g of yellow oil) is used on the next step.

Provenance & Evidence