Hydrochloric Acid → HCID 89838555, compound

Participants

Reaction Conditions

Reaction Steps

To 3.5 g of N-(tert-butyloxycarbonyl)-N′-(3-tert-butyl-4-methoxy-benzyl)piperazine 30 ml of 10% HCl and 5 ml of ethanol are added, the mixture is stirred for 5 h at 20° C., and evaporated to dryness in vacuum at 50÷80° C. Then 20 ml of dry acetone is added to the residue, the mixture is boiled with stifling for 20 min, then cooled down to 10° C. After 1 h the product is filtered off, washed with 10 ml of acetone and dried at the air. Yield of (3-tert-butyl-4-methoxybenzyl)piperazine dihydrochloride—2.2 g (68%).

Provenance & Evidence