Hydrochloric Acid → HCID 89838393, compound

Participants

Reaction Conditions

Reaction Steps

To 4.1 g of N-(tert-butyloxycarbonyl)-N′-(3,5-dimethoxy-4-ethoxy-benzyl)piperazine 40 ml of 10% HCl and 10 ml of ethanol are added, the mixture is stirred for 5 h at 20° C., and evaporated to dryness in vacuum at 50÷80° C. Then 30 ml of dry acetone is added to the residue, the mixture is boiled with stifling for 20 min, cooled down to 10° C. White precipitate is filtered off in an hour, washed with 10 ml of acetone and dried at the air. The product (2 g) is used on the next step without further purification.

Provenance & Evidence