tert-Butyl piperazine-1-carboxylate → HCID 89838038, compound

Participants

Reaction Conditions

Reaction Steps

The synthesis is carried out in argon condition. 2.2 g (11.8 mmol) of N-Boc-piperazine and 2.5 g (about 12 mmol) of crude 4-(2-methylpropyloxy)-3-methoxybenzaldehyde are mixed in 50 ml of dry of dichloromethane. After dissolution 2 drops of acetic acid is added, then 4.25 g (20 mmol) of NaBH(OAc)3 is added and the mixture is stirred for 12 h at 20° C. Then 20 ml of 5% NaHCO3 aqueous solution is added dropwise with care to the reaction mixture. The organic layer is separated, washed with 5% Na2CO3 solution, dried over sodium sulfate, filtered off, concentrated in vacuum at 50÷80° C. The residue (3.3 g of oil)-crude N-(tert-butyloxycarbonyl)-N′-(4-(2-methylpropyloxy)-3-methoxybenzyl)piperazine is used on the next step without further purification.

Provenance & Evidence