Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1771187Generated: November 2, 2026

N-Cbz-N-methyl-2-aminoethanol → Benzyl 2-(di-tert-butoxyphosphoryloxy)ethyl(methyl)carbamate

https://huagongshe.com/reaction/1771187

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Cbz-N-methyl-2-aminoethanolHCID 13279869—
ReactantBenzyl 2-(di-tert-butoxyphosphoryloxy)ethyl(ethyl)carbamateHCID 58080156—
ProductBenzyl 2-(di-tert-butoxyphosphoryloxy)ethyl(methyl)carbamateHCID 5808011267%

Reaction Steps

A similar procedure to that described for INTERMEDIATE 48 utilizing benzyl 2-hydroxyethyl(methyl)carbamate (INTERMEDIATE 51, 0.46 g, 2.20 mmol) as starting material was followed, with subsequent purification by column chromatography (ISCO, 12 g silica gel column, eluting with 0→100% EtOAc/hexanes) to give the title product (590 mg, yield: 67%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09248140B2
Source datasetuspto-grants-2016_02
ORD IDord-0b4294a74ec5427d9b7216225b817cd0
Source noteuspto-grants-2016_02