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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1771188Generated: November 4, 2026

Benzyl 2-(di-tert-butoxyphosphoryloxy)ethyl(methyl)carbamate → Di-tert-butyl 2-(methylamino)ethyl phosphate

https://huagongshe.com/reaction/1771188

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl 2-(di-tert-butoxyphosphoryloxy)ethyl(methyl)carbamateHCID 58080112—
ReactantDi-tert-butyl 2-(ethylamino)ethyl phosphateHCID 58080210—
ProductDi-tert-butyl 2-(methylamino)ethyl phosphateHCID 5808019695%

Reaction Steps

A similar procedure to that described for INTERMEDIATE 49 utilizing benzyl 2-(di-tert-butoxyphosphoryloxy)ethyl(methyl)carbamate (INTERMEDIATE 52, 0.59 g, 1.47 mmol) as starting material was followed, to give the title product (370 mg, yield: 95%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09248140B2
Source datasetuspto-grants-2016_02
ORD IDord-ba59e43b81104de9bcc5b6c5c1b21545
Source noteuspto-grants-2016_02