3-Methoxyphenylglyoxal hydrate → 3-(Methylsulfanyl)-5-(3-methoxyphenyl)-1,2,4-triazine

HRID 1771294Notes

Reaction equation

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].O.[CH3:8][O:9][C:10]1[CH:11]=[C:12]([C:16]([CH:18]=O)=O)[CH:13]=[CH:14][CH:15]=1>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:18]=[C:16]([C:12]2[CH:13]=[CH:14][CH:15]=[C:10]([O:9][CH3:8])[CH:11]=2)[N:4]=1

Participants

Reactant 2

HCID 211553973-Methoxyphenylglyoxal hydrate

HCID 178504051Methyl hydrazinecarbimidothioate

Product 1

HCID 128544163-(Methylsulfanyl)-5-(3-methoxyphenyl)-1,2,4-triazineYield 79%

Procedure

3-(Methylsulfanyl)-5-(3-methoxyphenyl)-1,2,4-triazine (1.01 g, 79%) was prepared from methyl hydrazinecarbimidothioate (0.58 g, 5.50 mmol) and 3-methoxyphenylglyoxal monohydrate (1.00 g, 5.50 mmol) according to the general procedure of Preparation 2.

Workup

customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record: ord-5a8d41ad9b6e457c9b9bb6d570e88250
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249130B2

Reaction notes

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