HCID 86676113, compound → 3-(Methylsulfanyl)-5-(3-chloro-5-fluorophenyl)-1,2,4-triazine

HRID 1771300Notes

Reaction equation

[NH:1]([C:3]([S:5][CH3:6])=[NH:4])[NH2:2].[Cl:7][C:8]1[CH:9]=[C:10]([C:15](=O)[CH:16]=O)[CH:11]=[C:12]([F:14])[CH:13]=1>>[CH3:6][S:5][C:3]1[N:1]=[N:2][CH:16]=[C:15]([C:10]2[CH:11]=[C:12]([F:14])[CH:13]=[C:8]([Cl:7])[CH:9]=2)[N:4]=1

Participants

Reactant 2

HCID 86676113HCID 86676113, compound

HCID 178504051Methyl hydrazinecarbimidothioate

Product 1

HCID 673657063-(Methylsulfanyl)-5-(3-chloro-5-fluorophenyl)-1,2,4-triazineYield 38.6%

Procedure

3-(methylsulfanyl)-5-(3-chloro-5-fluorophenyl)-1,2,4-triazine (16 g, 38.4%) was prepared from methyl hydrazinecarbimidothioate (25.5 g, 243 mmol) and 2-(3-chloro-5-fluorophenyl)-2-oxoacetaldehyde (30 g, 162 mmol) according to the general procedure of Preparation 2.

Workup

customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record: ord-8900fa1218aa4fecae48ea841c334aef
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249130B2

Reaction notes

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