Ammonia → HCID 67365112, compound

HRID 1771301Notes

Reaction equation

HRID 1771301 reaction equation
CS([C:5]1[N:6]=[N:7][CH:8]=[C:9]([C:11]2[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([Cl:18])[CH:12]=2)[N:10]=1)(=O)=O.[NH3:19]>>[Cl:18][C:13]1[CH:12]=[C:11]([C:9]2[N:10]=[C:5]([NH2:19])[N:6]=[N:7][CH:8]=2)[CH:16]=[C:15]([F:17])[CH:14]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 67364411HCID 67364411, compound

Product 1

HCID 67365112HCID 67365112, compoundYield 73%

Procedure

5-(3-chloro-5-fluorophenyl)-1,2,4-triazin-3-amine (1.70 g, 73%) was prepared from 3-(methylsulfonyl)-5-(3-chloro-5-fluorophenyl)-1,2,4-triazine (16.0 g, 55.5 mmol) and ammonia gas according to the general procedure of Preparation 2.

Workup

  1. customaccording to the general procedure of Preparation 2

Sources & evidence

ORD record
ord-6420c24c8be04852b97cf6440d686b01
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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