(3-Methoxyphenyl)boronic acid → 6-(3-Methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine

HRID 1771312Notes

Reaction equation

HRID 1771312 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1>>[CH3:15][O:16][C:17]1[CH:22]=[C:21]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 2734370(3-Methoxyphenyl)boronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 533545226-(3-Methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amineYield 47.6%

Procedure

6-(3-Methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine (106 mg, 47%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.21 g, 0.8 mmol) and 3-methoxyphenyl boronic acid (0.137 g, 0.90 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-be1429ee82ee452b87ea9f69cb75f49d
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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