(3-Fluoro-5-methoxyphenyl)boronic acid → HCID 53354725, compound

HRID 1771327Notes

Reaction equation

HRID 1771327 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[C:20]([O:22][CH3:23])[CH:21]=1>>[F:15][C:16]1[CH:17]=[C:18]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:19]=[C:20]([O:22][CH3:23])[CH:21]=1

Participants

3

Reactant 2

HCID 2763243(3-Fluoro-5-methoxyphenyl)boronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53354725HCID 53354725, compoundYield 32.7%

Procedure

6-(3-Fluoro-5-methoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine (193 mg, 32%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.50 g, 1.99 mmol) and 3-fluoro-5-methoxy phenylboronic acid (0.37 g, 2.19 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-9841a572e1304cacb5f2329b36a98afa
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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