1H-Indol-6-ylboronic acid → HCID 53354108, compound

HRID 1771328Notes

Reaction equation

HRID 1771328 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21](B(O)O)[CH:22]=2)[CH:17]=[CH:16]1>>[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:2]3[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=3[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:22]=2)[CH:17]=[CH:16]1

Participants

3

Reactant 2

HCID 27632051H-Indol-6-ylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53354108HCID 53354108, compoundYield 23.4%

Procedure

6-(1H-Indol-6-yl)-5-phenyl-1,2,4-triazin-3-amine (107 mg, 23%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.4 g, 1.59 mmol) and indol-6-boronic acid (0.256 g, 1.59 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-88e6a3a2da094548ac6fb5e9eb29c3e3
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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