3,4-Dimethylphenylboronic acid → HCID 53353233, compound

HRID 1771336Notes

Reaction equation

HRID 1771336 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][C:21]=1[CH3:22]>>[CH3:15][C:16]1[CH:17]=[C:18]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:19]=[CH:20][C:21]=1[CH3:22]

Participants

3

Reactant 2

HCID 27343483,4-Dimethylphenylboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353233HCID 53353233, compoundYield 67%

Procedure

6-(3,4-Dimethylphenyl)-5-phenyl-1,2,4-triazin-3-amine (55 mg, 67%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and 3,4-dimethylphenylboronic acid (51.5 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-5323295722354a14bdaff21a2f01509a
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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