(3-Acetamidophenyl)boronic acid → HCID 53353235, compound

HRID 1771338Notes

Reaction equation

HRID 1771338 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:15]([NH:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[CH:23][CH:24]=1)(=[O:17])[CH3:16]>>[NH2:8][C:5]1[N:6]=[N:7][C:2]([C:23]2[CH:24]=[C:19]([NH:18][C:15](=[O:17])[CH3:16])[CH:20]=[CH:21][CH:22]=2)=[C:3]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1

Participants

3

Reactant 2

HCID 157274(3-Acetamidophenyl)boronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353235HCID 53353235, compoundYield 64.6%

Procedure

N-[3-(3-Amino-5-phenyl-1,2,4-triazin-6-yl)phenyl]acetamide (59 mg, 62%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (75 mg, 0.299 mmol) and 3-acetamidophenylboronic acid (61.5 mg, 0.344 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-006a40a891134784a58094c1f756f940
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

Loading…