3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 53353237, compound

HRID 1771344Notes

Reaction equation

HRID 1771344 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]([F:28])([F:27])[O:17][C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=1>>[F:15][C:16]([F:27])([F:28])[O:17][C:18]1[CH:23]=[C:22]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 27343853-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353237HCID 53353237, compoundYield 25.7%

Procedure

6-(3-trifluoromethoxyphenyl)-5-phenyl-1,2,4-triazin-3-amine (170 mg, 25%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.50 g, 1.99 mmol) and 3-(trifluoromethoxy)phenyl boronic acid (0.44 g, 2.13 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-6d73573e8cab4d4d8b83ecc13f944c94
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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