3-Isopropylbenzeneboronic acid → HCID 53353325, compound

HRID 1771346Notes

Reaction equation

HRID 1771346 reaction equation
Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH:15]([C:18]1[CH:19]=[C:20](B(O)O)[CH:21]=[CH:22][CH:23]=1)([CH3:17])[CH3:16]>>[C:9]1([C:3]2[N:4]=[C:5]([NH2:8])[N:6]=[N:7][C:2]=2[C:22]2[CH:21]=[CH:20][CH:19]=[C:18]([CH:15]([CH3:17])[CH3:16])[CH:23]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 27734783-Isopropylbenzeneboronic acidHCID 866761146-Bromo-5-phenyl-1,2,4-triazin-3-amine

Product 1

HCID 53353325HCID 53353325, compoundYield 33%

Procedure

5-phenyl-6-[3-(propan-2-yl)phenyl]-1,2,4-triazin-3-amine (110 mg, 33%) was prepared from 6-bromo-5-phenyl-1,2,4-triazin-3-amine (0.3 g, 1.19 mmol) and 3-isopropyl phenyl boronic acid (0.215 g, 1.31 mmol) according to the general procedure of Example 1.

Sources & evidence

ORD record
ord-308bbcb2a4fe448b9ced7408fd5e017d
Source dataset
uspto-grants-2016_02
Patent number
US09249130B2

Reaction notes

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