Potassium Carbonate → HCID 123615096, compound

Participants

Reaction Steps

To a solution of 5-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)pyridin-2-ol (1.10 g, 4.74 mmol) in MeCN (10.0 mL) was added (2-bromoethoxy)(tert-butyl)dimethylsilane (1.28 mL, 5.68 mmol) and K2CO3 (0.785 g, 5.68 mmol) and the mixture heated to reflux for 6 hr. The resulting mixture was cooled and was loaded directly onto silica and purified by flash column chromatography (SiO2, 40 g, 0-100% EtOAc in isohexane, gradient elution) to afford the title compound, Intermediate A15, as a pale yellow solid (1.11 g, 60%); Rt 2.61 min (Method 2, acidic); m/z 391 (M+H)+, (ES+).

Provenance & Evidence