Ethyl chloroformate → HCID 178473418, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-nitro-1H-indazol-3-ol (1.00 g, 5.60 mmol) in pyridine (6.0 mL) was added ethyl carbonochloridate (0.590 μL, 6.14 mmol) and the reaction mixture was heated to 70° C. After 3 hr the reaction mixture was cooled to RT and evaporated in vacuo. The residue was triturated with water (50 mL) to afford ethyl 3-hydroxy-5-nitro-1H-indazole-1-carboxylate as a yellow solid (1.26 g, 85%); Rt 1.70 min (Method 2, acidic); m/z 252 (M+H)+ (ES+).

Provenance & Evidence