HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylphenethyl alcohol → HCID 55250755, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylphenethyl alcohol | HCID 88267 | — |
| Reactant | 2,2-Dihydroxyacetic acid | HCID 2723641 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 55250755 | HCID 55250755 | 92.1% |
Reaction Steps
The mixture of 2-(2-methylphenyl)ethanol (2 g), TFA (10 ml) and 2,2-dihydroxyacetic acid (1.5 g) was refluxed for 23 hrs and volatiles were evaporated. Separation method I yielded the title compound (2.6 g) as an off-white solid. Alternatively, sulphuric acid can be used in cyclization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09249127B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-ad679cb965044769894037075a61d02c |
| Source note | uspto-grants-2016_02 |